反应详情

温度

-78 °C

1-Benzyloxy-2-chloro-4-(2,2,2-trifluoro-ethyl)benzene (4.0 g, 13.0 mmol) was dissolved in dichloromethane (50 mL) and cooled to −78° C. A solution of boron tribromide (1.0 M in CH2Cl2, 14.3 mL, 14.3 mmol) was added. The reaction mixture was warmed to 0° C., diluted with dichloromethane and washed with brine. After removal of solvent, the residue was chromatographed on silica gel eluting with 9:1 hexane:ethyl acetate to give the title compound.

1. temperatureThe reaction mixture was warmed to 0° C.
2. washwashed with brine
3. customAfter removal of solvent
4. customthe residue was chromatographed on silica gel eluting with 9:1 hexane