HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-tert-Butyl-5-hydroxy-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester → (2R)-2-tert-Butyl-5-{3-[2-chloro-4-(2,2,2-trifluoro-ethyl)-phenoxy]-propoxy}-2,3-dihydro-benzofuran-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-tert-Butyl-5-hydroxy-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester | HCID 11459363 | — |
| Reactant | Benzene, 2-chloro-1-(3-iodopropoxy)-4-(2,2,2-trifluoroethyl)- | HCID 69050445 | — |
| Product | (2R)-2-tert-Butyl-5-{3-[2-chloro-4-(2,2,2-trifluoro-ethyl)-phenoxy]-propoxy}-2,3-dihydro-benzofuran-2-carboxylic acid | HCID 57643419 | — |
Reaction Steps
The title compound was prepared following the general procedure described in Example 1, Step 4, employing the chiral phenol prepared in step 1 and the iodide prepared in Example 14, Step 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07524882B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-4e22ef240be448e5a72ab665249a9b1f |
| Source note | uspto-grants-2009_04 |