HCID 57642292, compound → HCID 16733463, compound

Participants

Reaction Steps

[tert-Butoxycarbonyl-(3-{2-[5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl]-acetylamino}-phenyl)-amino]-acetic acid (Example 51)(137 mg, 0.21 mmol) was stirred in trifluoroacetic acid for 2 h at room temperature. After concentration, the resulting gum was dissolved in DCM, washed with saturated NaHCO3 and then with 1N HCl. The organic phase was dried over MgSO4, filtered and the solvent was evaporated to afford the title compound as a yellow solid (85 mg, 73%). 1H NMR (DMSO-d6) 9.47 (1H, s), 7.55-7.27 (2H, m), 7.23-7.15 (2H, m), 6.97 (1H, t), 6.92-6.68 (2H, m), 6.25 (1H, m), 5.80 (2H, br s), 4.78 (2H, m), 4.25 (1H, d), 3.95 (1H, d), 3.72 (2H, s), 2.80 (1H, m), 1.86-1.51 (6H, m), 1.26-1.09 (13H, m). The compound was further characterised as the N-methyl-D-glucamine salt. Found: C, 57.66; H, 7.45; N, 9.07%; C30H36N4O6.C7H17NO5.1.5H2O requires: C, 57.65; H, 7.32; N, 9.09%.

Provenance & Evidence