Dimethyl(methylene)ammounium iodide → HCID 68406409, compound

Participants

Reaction Steps

In analogy to example 5b, 2-fluoro-6-(4-methyl-imidazol-1-yl)-benzonitrile was reacted with Eschenmoser's salt in DMF for 7 h at 90° C. Evaporation of the solvent, extractive workup and chromatography (SiO2, dichloromethane:methanol=100:0 to 97:3) furnished the title compound as a light yellow solid (yield: 46%). 1H-NMR (400 MHz, DMSO): δ=1.94 (s, 6H), 2.17 (s, 3H), 3.23 (s, 2H), 7.61-7.67 (m, 2H), 7.86 (s, 1H), 7.86-7.96 (m, 1H).

Provenance & Evidence