Dimethyl(methylene)ammounium iodide → HCID 69106626, compound

Participants

Reaction Steps

In analogy to example 5b, 3-fluoro-2-(4-methyl-imidazol-1-yl)-benzonitrile was reacted with Eschenmoser's salt in DMF for 16 h at 90° C. Evaporation of the solvent, aqueous workup and chromatography (SiO2, dichloromethane:methanol=100:0 to 98:2) afforded the title compound as a light yellow oil (yield: 13%). 1H-NMR (400 MHz, DMSO): δ=1.91 (s, 6H), 2.17 (s, 3H), 3.17 (s, 2H), 7.72-7.92 (m, 4H)

Provenance & Evidence