HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Toluene-4-sulfonic acid piperidin-3-ylmethyl ester, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 3-((P-tolylsulfonyloxy)methyl)piperidine-1-carboxylate | HCID 18369320 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Toluene-4-sulfonic acid piperidin-3-ylmethyl ester, hydrochloride | HCID 131727084 | — |
Reaction Steps
A mixture of 8.5 g (23 mmol) 3-(toluene-4-sulfonyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester and 28.7 mL (115 mmol) 4N HCl in dioxane in 30 mL dioxane was evaporated to dryness. This yielded 7.57 g (97%) of the title compound as viscous yellow oil which was used without further purification. MS(m/e): 270 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07432255B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-61d7ee3be3b744eca50cc8cfa7ac8a41 |
| Source note | uspto-grants-2008_10 |