Hydrochloric Acid → HCID 68621990, compound

Participants

Reaction Conditions

Reaction Steps

4-[5-(4-isopropyl-piperazine-1-carbonyl)-indol-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (example 26) was treated with 4N HCl in dioxane and evaporated to dryness. The residue was used in the consecutive step without further purification. The residue was dissolved in THF and treated with KOtBu. Propyliodide was added and heated to 60° C. After evaporation to dryness the residue was dissolved in methanol/DMF and subjected to purification by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile/water/NEt3. The combined product fractions were evaporated to the title compound. MS (m/e): 397.3 (MH+).

Provenance & Evidence