HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 86600596, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (3R)-3-Aminopiperidine, 3-BOC protected | HCID 1514172 | — |
| Reactant | HCID 86600595 | HCID 86600595 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 86600596 | HCID 86600596 | — |
Reaction Steps
A solution of 0.14 g 1-(but-2-ynyl)-2-chloro-5-cyanomethyl-6-(quinolin-2-ylmethyl)-5,6-dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dione, 0.15 g potassium carbonate and 0.07 g (R)-3-tert-butoxycarbonylaminopiperidine in 2 ml dimethylsulphoxide is stirred for 5 h at 60° C. Then water is added and the mixture is extracted three times with ethyl acetate. The combined organic phases are dried over sodium sulphate, and then the solvent is removed. The residue is purified by chromatography on silica gel (cyclohexane/ethyl acetate 1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07432262B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-0e3b723d4dbd4058863155f71a0e1845 |
| Source note | uspto-grants-2008_10 |