HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2113509Generated: November 3, 2026
2-Chlorobenzimidazole → tert-Butyl 2-(((1H-benzo[d]imidazol-2-yl)amino)methyl)piperidine-1-carboxylate
https://huagongshe.com/reaction/2113509
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chlorobenzimidazole | HCID 78572 | — |
| Reactant | tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate | HCID 2756482 | — |
| Product | tert-Butyl 2-(((1H-benzo[d]imidazol-2-yl)amino)methyl)piperidine-1-carboxylate | HCID 71631700 | 30.8% |
Reaction Steps
(RS)-2-Aminomethyl-piperidine-1-carboxylic acid tert butyl ester (0.25 g) and 2-chlorobenzimidazole (0.15 g) were combined and warmed to 100° C. for 48 hours. After cooling to room temperature the mixture was column chromatographed (silica gel, ethyl acetate/pentane 1:4—ethyl acetate/pentane 1:1 eluant) to give the title compound (0.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07432270B2 |
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| Source dataset | uspto-grants-2008_10 |
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| ORD ID | ord-68766bc6e99d4d1f997f774f2e0c47a6 |
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| Source note | uspto-grants-2008_10 |
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