HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzothiazole → tert-Butyl 2-((benzo[d]thiazol-2-ylamino)methyl)piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzothiazole | HCID 11987 | — |
| Reactant | tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate | HCID 2756482 | — |
| Solvent | Diethyl ether hexane diethyl ether | HCID 22448964 | — |
| Product | tert-Butyl 2-((benzo[d]thiazol-2-ylamino)methyl)piperidine-1-carboxylate | HCID 71631715 | 37.1% |
Reaction Steps
The title compound (1.2 g) after column chromatography (silica gel, 5% diethyl ether/hexane-diethyl ether eluant) was prepared from (RS) 2-aminomethyl-piperidine-1-carboxylic acid tert butyl ester (2.0 g) and 2-chlorobenzothiazole (1.58 g) according to the method of D2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07432270B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-8072760e02ae4371811e5100bc4e34bf |
| Source note | uspto-grants-2008_10 |