2-Chloro-4-cyanopyridine → (S)-2-[(4-Cyano-pyridin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert butyl ester

HRID 2113531Notes

Reaction equation

HRID 2113531 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][NH2:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:17]1[CH:22]=[C:21]([C:23]#[N:24])[CH:20]=[CH:19][N:18]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][NH:15][C:17]1[CH:22]=[C:21]([C:23]#[N:24])[CH:20]=[CH:19][N:18]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 5686382-Chloro-4-cyanopyridineHCID 1502020tert-Butyl (2S)-2-(aminomethyl)piperidine-1-carboxylate

Product 1

HCID 86593679(S)-2-[(4-Cyano-pyridin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert butyl esterYield 14.3%

Procedure

The title compound (0.24 g) was prepared from (S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester (1.14 g) and 2-chloro-4-cyanopyridine (0.74 g) according to the method of D28.

Sources & evidence

ORD record
ord-6370b9ffe3734d6d91de9b0d49e664a8
Source dataset
uspto-grants-2008_10
Patent number
US07432270B2

Reaction notes

Loading…