HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-bromopyridine → 4-(6-Bromoimidazo[1,2-a]pyridin-2-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-bromopyridine | HCID 70622 | — |
| Reactant | 4-(Bromoacetyl)benzonitrile | HCID 98654 | — |
| Reactant | 2-(5-Bromofuran-2-yl)-imidazo[1,2-a]pyridine-6-carbonitrile | HCID 69253853 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(6-Bromoimidazo[1,2-a]pyridin-2-yl)benzonitrile | HCID 67403943 | 62% |
Reaction Steps
The same procedure described for 3a was used employing 4-Cyanophenacyl bromide and 2-Amino-5-bromopyridine. Yield 62%, mp 218-219° C. (EtOH). 1H NMR (DMSO-d6); δ 7.41 (d, J=8.7 Hz, 1H), 7.61 (d, J=8.7 Hz, 1H), 7.90 (d, J=8.4 Hz, 2H), 8.15 (d, J=8.4 Hz, 2H), 8.53 (s, 1H), 8.92 (s, 1H). 13C NMR; δ 143.5, 143.0, 137.9, 132.7, 128.5, 127.1, 126.1, 118.8, 117.9, 111.3, 110.0, 106.4. MS (m/z, rel.int.); 298 (M+, 100). Anal. (C14H8BrN3) C, H.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07432278B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-ea1a7d728a604f40b3da0c91ab2e4c7d |
| Source note | uspto-grants-2008_10 |