HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Bromoacetyl)benzonitrile → 4-(6-Bromo-8-methyl-imidazo[1,2-a]pyridin-2-yl)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Bromoacetyl)benzonitrile | HCID 98654 | — |
| Reactant | 2-Amino-5-bromo-3-methylpyridine | HCID 137934 | — |
| Reactant | 2-(5-Bromofuran-2-yl)-imidazo[1,2-a]pyridine-6-carbonitrile | HCID 69253853 | — |
| Product | 4-(6-Bromo-8-methyl-imidazo[1,2-a]pyridin-2-yl)-benzonitrile | HCID 69254566 | 71% |
Reaction Steps
The same procedure described for 3a was used employing 4-Cyanophenacyl bromide and 2-Amino-5-bromo-3-methylpyridine. Yield 71%, mp 209-210° C. 1H NMR (DMSO-d6); δ 2.56 (s, 3H), 7.53 (s, 1H), 7.95 (d, J=8.1 Hz, 2H), 8.14 (d, J=8.1 Hz, 2H), 8.60 (s, 1H), 8.88 (s, 1H). 13C NMR; δ 143.3, 140.4, 133.3, 133.0, 128.1, 127.4, 127.0, 125.9, 119.2, 112.8, 111.2, 108.2, 16.7. MS (m/z, rel.int.); 312 (M+, 10), 230 (100), 217 (60), 205 (50).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07432278B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-97a6a893d2254adaa189e343e17e95a8 |
| Source note | uspto-grants-2008_10 |