2-[5-(4-Cyanophenyl)-furan-2-yl]-imidazo[1,2-a]pyridine-6-carbonitrile → 2,6-Bis(4-cyanophenyl)-8-methyl-imidazo[1,2-a]pyridine

Participants

Role	Name	HCID	Charge
Reactant	2-[5-(4-Cyanophenyl)-furan-2-yl]-imidazo[1,2-a]pyridine-6-carbonitrile	HCID 69253840	—
Reactant	4-(6-Bromo-8-methyl-imidazo[1,2-a]pyridin-2-yl)-benzonitrile	HCID 69254566	—
Product	2,6-Bis(4-cyanophenyl)-8-methyl-imidazo[1,2-a]pyridine	HCID 69253855	73%

Reaction Steps

The same procedure described for 4a was used starting with 20. Yield 73%, mp 283-285° C. 1H NMR (DMSO-d6); δ 2.60 (s, 3H), 7.53 (s, 1H), 7.85-7.93 (m, 6H), 8.17 (d, J=8.4 Hz, 2H), 8.53 (s, 1H), 8.87 (s, 1H). 13C NMR; δ 144.9, 142.5, 141.1, 138.1, 132.6, 132.4, 127.0, 126.6, 126.0, 123.6, 123.3, 122.9, 118.6, 118.4, 111.9, 110.0, 109.7, 16.3. MS (m/z, rel.int.); 335 (M++1, 100), 310 (30), 279 (20), 234 (40).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07432278B2
Source dataset	uspto-grants-2008_10
ORD ID	ord-6a0c8eae5f9b4246b53d05b7f928ecea
Source note	uspto-grants-2008_10