3-Pyridinemethanamine → HCID 69317441, compound

Participants

Reaction Steps

Following the procedure described above in Example 29, 4-chloro-6-fluoro-1,7-naphthyridine-3-carbonitrile (0.200 g, 0.963 mmol) was reacted with 4-(trifluoromethoxy)aniline (0.14 mL, 0.19 g, 1.1 mmol), then with 3-(aminomethyl)pyridine. The crude product was purified twice by preparative HPLC, and lyophilized to give a fluffy, bright yellow solid (16 mg, 3.8% yield): 1H NMR (400 MHz, DMSO-D6) δ 4.57 (d, J=6.6 Hz, 2 H) 7.12 (s, 1 H) 7.33 (dd, J=7.6, 4.8 Hz, 1 H) 7.38 (s, 4 H) 7.52 (t, J=6.1 Hz, 1 H) 7.75 (d, J=7.6 Hz, 1 H) 8.29 (s, 1 H) 8.43 (d, J=3.8 Hz, 1 H) 8.59 (s, 1 H) 8.86 (s, 1 H) 9.67 (s, 1 H).

Provenance & Evidence