2-Morpholinoethylamine → HCID 69320856, compound

Participants

Reaction Steps

Following the procedure described above in Example 34, 6-fluoro-4-(1H-indol-5-ylamino)-1,7-naphthyridine-3-carbonitrile was reacted with 2-morpholin-4-yl-ethylamine. The crude product was purified by flash column chromatography (2 to 10% methanol in methylene chloride) to give a yellow solid (0.103 g, 55%). 1H NMR (400 MHz, DMSO-D6) δ ppm 2.4 (m, 4 H) 2.6 (t, J=6.8 Hz, 2 H) 3.4 (m, 2 H) 3.6 (m, 4 H) 6.5 (m, 2 H) 7.1 (dd, J=8.5, 1.9 Hz, 1 H) 7.2 (s, 1 H) 7.4 (m, 1 H) 7.4 (d, J=8.6 Hz, 1 H) 7.5 (d, J=1.8 Hz, 1 H) 8.1 (s, 1 H) 8.8 (s, 1 H) 9.7 (s, 1 H) 11.2 (s, 1 H).

Provenance & Evidence