Benzylamine → 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(phenylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

Participants

Reaction Steps

Following the procedure described above in Example 34, 4-(3-Chloro-4-fluoro-phenylamino)-6-fluoro-[1,7]naphthyridine-3-carbonitrile was reacted with benzylamine. The crude product was purified by flash column chromatography (1% methanol in methylene chloride) to give a yellow solid (0.051 g, 54%). 1H NMR (400 MHz, DMSO-D6) δ ppm 4.5 (d, J=6.3 Hz, 2 H) 7.0 (s, 1 H) 7.2 (t, J=7.2 Hz, 1 H) 7.3 (m, 5 H) 7.5 (m, 2 H) 7.6 (dd, J=6.6, 2.5 Hz, 1 H) 8.3 (s, 1 H) 8.9 (s, 1 H) 9.6 (s, 1 H).

Provenance & Evidence