HCID 11708258, compound → HCID 59789301, compound

HRID 2113604Notes

Reaction equation

HRID 2113604 reaction equation
[Br-:1].[Br-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[F:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[C:25]([CH2:35]O)[CH:24]=1>C(Cl)(Cl)Cl>[Br:1][CH2:35][C:25]1[CH:24]=[C:23]([F:22])[CH:28]=[CH:27][C:26]=1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

4

Reactant 2

HCID 11708258HCID 11708258, compoundHCID 12890784Triphenylphosphane dibromide

Product 1

HCID 59789301HCID 59789301, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
60 °C

Procedure

Triphenylphosphine dibromide (35.5 g, 2 eq) was added in one portion to a solution of (4-fluoro-[1,1′-biphenyl]-2-yl)methanol (8.5 g, 42 mmol) in chloroform (250 mL). The reaction mixture was heated at 60° C. and left to stir overnight. The solid was filtered off and the solvent removed in vacuo. The resulting oil was purified by flash chromatography on silica, eluting with ethyl acetate/cyclohexane (0:100 to 30:70), to give the title compound as an oil.

Workup

  1. waitleft
  2. filtrationThe solid was filtered off
  3. customthe solvent removed in vacuo
  4. customThe resulting oil was purified by flash chromatography on silica
  5. washeluting with ethyl acetate/cyclohexane (0:100 to 30:70)

Sources & evidence

ORD record
ord-d17ec11dadbd492299ac363d36fe19e6
Source dataset
uspto-grants-2008_10
Patent number
US07432280B2

Reaction notes

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