HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2113606Generated: October 30, 2026
Sodium Carbonate → 2-p-Tolyl-3-trifluoromethyl-pyridine
https://huagongshe.com/reaction/2113606
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Tolylboronic acid | HCID 79799 | — |
| Reactant | 2-Chloro-3-(trifluoromethyl)pyridine | HCID 589833 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 2-p-Tolyl-3-trifluoromethyl-pyridine | HCID 22030373 | — |
Reaction Steps
To a de-gassed mixture of 2-chloro-3-(trifluoromethyl)-pyridine (70.1 mmol), p-tolylboronic acid (70.6 mmol), and 2M Na2CO3 (175.0 mmol) in DME (200 mL) under nitrogen, add Pd(PPh3)4 (2.8 mmol). Stir the mixture at 80° C. overnight, concentrate, and extract with EtOAc. Dry over Na2SO4, concentrate under vacuum, and pass through a silica gel pad to give 2-p-tolyl-3-trifluoromethyl-pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07432275B2 |
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| Source dataset | uspto-grants-2008_10 |
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| ORD ID | ord-fa1313a747bf4348a2d013448279051b |
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| Source note | uspto-grants-2008_10 |
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