2-Nitro4-(3-trifluoromethyl-pyridin-2-yl)-benzamide → 2-Amino4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

HRID 2113608Notes

Reaction equation

HRID 2113608 reaction equation
[N+:1]([C:4]1[CH:12]=[C:11]([C:13]2[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:10]=[CH:9][C:5]=1[C:6]([NH2:8])=[O:7])([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:12]=[C:11]([C:13]2[C:18]([C:19]([F:22])([F:20])[F:21])=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:10]=[CH:9][C:5]=1[C:6]([NH2:8])=[O:7]

Participants

4

Reactant 1

HCID 220300502-Nitro4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

Product 1

HCID 220300742-Amino4-(3-trifluoromethyl-pyridin-2-yl)-benzamide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Hydrogenate 2-nitro-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide (1.0 g, 0.0032 mol) with 50 psi of H2 and 100 mg of 10% Pd/C in ethanol. After 16 hours, filter the mixture through celite and concentrate under reduced pressure to give 2-amino-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide as a solid.

Workup

  1. filtrationfilter the mixture through celite
  2. concentrationconcentrate under reduced pressure

Sources & evidence

ORD record
ord-05b91ad7973b469c8228c48529e1262a
Source dataset
uspto-grants-2008_10
Patent number
US07432275B2

Reaction notes

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