HRID2113614

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)c1ccc(Nc2nc(COP(=O)(OCc3ccccc3)OCc3ccccc3)nc3cc(-c4ncccc4C(F)(F)F)ccc23)cc1

HCID9987362

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)c1ccc(Nc2nc(COP(=O)(O)O)nc3cc(-c4ncccc4C(F)(F)F)ccc23)cc1

HCID10007240

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Dissolve phosphoric acid dibenzyl ester 4-(4-tert-butyl-phenylamino)-7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-2-ylmethyl ester (225 mg, 0.316 mmol) in methanol and add 10% palladium on carbon (218 mg). Stir the solution for 2 hours under 1 atmosphere of hydrogen gas. Filter the solution through celite and wash through with additional methanol. Concentrate under reduced pressure and triturate with ether to yield the desired product as a yellow solid.

WORKUP

后处理

filtrationFilter the solution through celite
washwash through with additional methanol
concentrationConcentrate under reduced pressure
customtriturate with ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5ff7288dc24447ca9f13e0f433722e70
来源数据集: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07432275B2
来源说明: uspto-grants-2008_10

反应 SMILES

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([C:22]4[C:27]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:25]=[CH:24][N:23]=4)=[CH:19][CH:20]=3)[N:15]=[C:14]([CH2:32][O:33][P:34](=[O:51])([O:43]CC3C=CC=CC=3)[O:35]CC3C=CC=CC=3)[N:13]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([NH:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([C:22]4[C:27]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:25]=[CH:24][N:23]=4)=[CH:19][CH:20]=3)[N:15]=[C:14]([CH2:32][O:33][P:34](=[O:35])([OH:43])[OH:51])[N:13]=2)=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]