Sodium Hydroxide → HCID 69312206, compound

Participants

Reaction Steps

To a solution of 1-(2-{2-tert-butyl-5-[7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-4-ylamino]-phenoxy}-ethyl)-pyrrolidine-2-carboxylic acid methyl ester (59 mg, 0.1 mmol) in methanol (5 ml) add sodium hydroxide (12 mg, 0.3 mmol). Stir the mixture for 12 hours and evaporate to dryness. Add water (2 ml) and 1M hydrochloric acid (until pH=7.0) and extract with ethyl acetate. Wash the combined extracts with brine, dry (MgSO4) and concentrate under reduced pressure to give the title compound. MS 580 (M+1).

Provenance & Evidence