Diethyl Oxalate → HCID 178470307, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 6-amino-3′-methyl-[2,2′]bipyridinyl-5-carboxylic acid amide (1.00 g, 4.38 mmol, prepared in a manner analogous to that described above for the preparation of 6-amino-3′-chloro-[2,2′]bipyridinyl-5-carboxylic acid amide) in diethyl oxalate (24 mL) and heat the mixture at 160° C. for 8 hours or until all starting material is gone as indicated by TLC. Pour the hot mixture onto ice and extract with CH2Cl2 (2×100 mL). Dry the combined organic extracts over Na2SO4. Remove the solvent under reduced pressure. Chromatograph the crude product on silica gel eluting first with CH2Cl2 followed by CH2Cl2/MeOH (95:5) to yield the title compound. MS 311.12 (M+1).

Provenance & Evidence