Hydrochloric Acid → HCID 59811135, compound

Participants

Reaction Steps

Dissolve 4-(4-t-butyl-phenylamino)-7-(3-methyl-pyridin-2-yl)-pyrido[2,3-d]pyrimidine-2-carboxylic acid ethyl ester (25 mg, 0.57 mmol) and LiOH.H2O (8 mg, 0.17 mmol) in a solution of THF (2.5 mL) and H2O (0.2 mL). Stir the mixture overnight at room temperature. Add water 10 mL and acidify with 3 N HCl. Extract the mixture with EtOAc (3×10 mL). Wash the combined organic extracts with brine and dry over Na2SO4. Remove the solvent under reduced pressure to yield the title compound. MS 414.18 (M+1).

Provenance & Evidence