反应详情

温度

100 °C

Dissolve 3-(5-cyano-3′-trifluoromethyl-[2,2′]bipyridinyl-6-yl)-2-oxo-propionic acid ethyl ester (70 mg, 0.193 mmol) and 4-trifluoromethyl aniline (31 mg, 0.193 mmol) in AcOH (1 mL). Heat the mixture at 100° C. for 1.5 hours. Cool the mixture in ice and add H2O (5 mL). Extract three times with EtOAC (3×10 mL). Combine the organic extracts and wash with 1 N NaOH (30 mL) and brine (30 mL). Dry the organic extract over Na2SO4 and remove the solvent under reduced pressure. Purify the crude product using silica gel chromatography eluting with hexane/acetone (3:1) to yield the title compound. MS 507.15 (M+1)

1. temperatureCool the mixture in ice
2. extractionExtract three times with EtOAC (3×10 mL)
3. washCombine the organic extracts and wash with 1 N NaOH (30 mL) and brine (30 mL)
4. customDry the
5. extractionorganic extract over Na2SO4
6. customremove the solvent under reduced pressure
7. customPurify the crude product
8. washeluting with hexane/acetone (3:1)