HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Chloro-4-(chloromethyl)-6-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2-Chloro-6-methylpyridin-4-yl)methanol | HCID 22504306 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Chloro-4-(chloromethyl)-6-methylpyridine | HCID 21698167 | — |
Reaction Steps
2.2 1.14 g of (2-chloro-6-methylpyridin-4-yl)methanol are initially introduced in 50 ml of toluene, and 1.05 ml of thionyl chloride are slowly added dropwise with ice cooling. The mixture is boiled under reflux overnight. After cooling, the solvent is removed, giving 2-chloro-4-chloromethyl-6-methylpyridine as brown oil (1.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07432282B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-e624334278f045eebad3125f2b59d0fb |
| Source note | uspto-grants-2008_10 |