HRID2113730

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1049

Pyridine

C5H5N

HCID2735713

5-[(4-Chlorobenzamido)methyl]thiophene-2-sulfonyl chloride

C12H9Cl2NO3S2

HCID2744372

2-[4-(1,3-dithiolan-2-yl)phenyl]-1,3-thiazole-4-carbohydrazide

C13H13N3OS3

PRODUCTS

产物

HCID9960944

未命名化合物

收率 80%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

A solution of sulfonyl chloride 1b (1.0 equivalents), 2-[4-(1,3-Dithiolan-2-yl)phenyl]-1,3-thiazole-4-carbohydrazide (1.1 equivalents), and pyridine (1.2-2 equivalents) in CHCl3 is heated to reflux for 2 h. Filtration over SiO2 (CH3CN) and evaporation yielded 80% of the desired sulfonyl hydrazide 1.

WORKUP

后处理

temperatureto reflux for 2 h
filtrationFiltration
customover SiO2 (CH3CN) and evaporation

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-6f864594fc2946c4bb1c156b12f505ec
来源数据集: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07432286B1
来源说明: uspto-grants-2008_10

反应SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:10][CH2:11][C:12]2[S:16][C:15]([S:17](Cl)(=[O:19])=[O:18])=[CH:14][CH:13]=2)=[O:9])=[CH:4][CH:3]=1.[S:21]1[CH2:25][CH2:24][S:23][CH:22]1[C:26]1[CH:31]=[CH:30][C:29]([C:32]2[S:33][CH:34]=[C:35]([C:37]([NH:39][NH2:40])=[O:38])[N:36]=2)=[CH:28][CH:27]=1.N1C=CC=CC=1>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:10][CH2:11][C:12]2[S:16][C:15]([S:17]([NH:40][NH:39][C:37]([C:35]3[N:36]=[C:32]([C:29]4[CH:28]=[CH:27][C:26]([CH:22]5[S:21][CH2:25][CH2:24][S:23]5)=[CH:31][CH:30]=4)[S:33][CH:34]=3)=[O:38])(=[O:19])=[O:18])=[CH:14][CH:13]=2)=[O:9])=[CH:4][CH:3]=1