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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2113741Generated: October 30, 2026

3-Pyridinemethanamine → 3-Chloro-4-phenyl-1-[(pyridin-3-yl)methyl]-1H-pyrrole-2,5-dione

https://huagongshe.com/reaction/2113741

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-PyridinemethanamineHCID 31018—
Reactant3-Chloro-4-phenylfuran-2,5-dioneHCID 23447195—
SolventAcetic AcidHCID 176—
Product3-Chloro-4-phenyl-1-[(pyridin-3-yl)methyl]-1H-pyrrole-2,5-dioneHCID 69145172—

Reaction Steps

A solution of 3-chloro-4-phenylfuran-2,5-dione (1.00 mmol, 209 mg) and 3-(aminomethyl)-pyridine (1.00 mmol, 26 mg) in glacial acetic acid (4 mL) was heated in a microwave reactor at 120° C. for two min. After cooling, the solvent was evaporated at reduced pressure. The crude product was used without purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07432288B2
Source datasetuspto-grants-2008_10
ORD IDord-015f37b0aa2a452dbb71214733c18070
Source noteuspto-grants-2008_10