HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-Chloro-1-[4-(dimethylamino)benzyl]-4-phenyl-1H-pyrrole-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-(aminomethyl)-N,N-dimethylaniline dihydrochloride | HCID 2734633 | — |
| Reactant | 3-Chloro-4-phenylfuran-2,5-dione | HCID 23447195 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-Chloro-1-[4-(dimethylamino)benzyl]-4-phenyl-1H-pyrrole-2,5-dione | HCID 69148011 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
To a solution of 3-chloro-4-phenylfuran-2,5-dione (0.20 mmol, 42 mg) and 4-dimethylaminobenzylamine dihydrochloride (0.20 mmol, 45 mg) in glacial acetic acid (1 mL) was added triethylamine (0.40 mmol). The mixture was heated in a microwave reactor at 120° C. for two min. After cooling, the solvent was evaporated at reduced pressure. The reaction mixture was purified by HPLC (95% 0.1M ammonium acetate buffer: 5% CH3CN→100% CH3CN).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07432288B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-d9a46a4d9eba4ec8b22273556ba49319 |
| Source note | uspto-grants-2008_10 |