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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2113743Generated: November 1, 2026

2-Pyridinemethanamine → 3-Chloro-4-phenyl-1-[(pyridin-2-yl)methyl]-1H-pyrrole-2,5-dione

https://huagongshe.com/reaction/2113743

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-PyridinemethanamineHCID 19509—
Reactant3-Chloro-4-phenylfuran-2,5-dioneHCID 23447195—
SolventAcetic AcidHCID 176—
Product3-Chloro-4-phenyl-1-[(pyridin-2-yl)methyl]-1H-pyrrole-2,5-dioneHCID 69148694—

Reaction Steps

A solution of 3-chloro-4-phenylfuran-2,5-dione (0.20 mmol, 42 mg) and 2-aminomethyl-pyridine (0.20 mmol, 22 mg) in glacial acetic acid (1 mL) was heated in a microwave reactor at 120° C. for two min. After cooling, the solvent was evaporated at reduced pressure. The crude product was used without purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07432288B2
Source datasetuspto-grants-2008_10
ORD IDord-694fa010af2740cab85e11a4c44ff026
Source noteuspto-grants-2008_10