Benzenamine, 4-(4-morpholinyl)- → HCID 11407140, compound

Participants

Reaction Conditions

Reaction Steps

3-Chloro-1-(2-methoxyethyl)-4-phenyl-1H-pyrrole-2,5-dione (0.26 mmol, 70 mg) and 4-morpholinoaniline (0.53 mmol, 94 mg) was dissolved in dry CH3CN (2 mL) and the reaction mixture was subjected to microwave heating single node 130° C. for 10 min and purified on SiO2 (EtOAc:heptane, 1:1) to give 96 mg (89%) of the title compound. 1H NMR (400 MHz, CD3CN) δ 7.73 (bs, 1H), 7.17-7.04 (m, 3H), 6.98-6.93 (m, 2H), 6.70-6.64 (m, 2H), 6.59-6.54 (m, 2H), 3.75-3.70 (m, 6H), 3.58 (t, J=5.6 Hz, 2H), 3.33 (s, 3H), 2.98-2.95 (m, 4H).

Provenance & Evidence