Propionyl chloride → HCID 69291516, compound

HRID 2113797Notes

Reaction equation

ClC1C=C(C)C=C(C)C=1N1CCCC2=C(N)N(C)N=C12.C[N:22]1[C:30]([NH2:31])=[C:29]2[C:24]([N:25]([C:32]3[C:37]([CH3:38])=[CH:36][C:35]([CH3:39])=[CH:34][C:33]=3[CH3:40])[CH2:26][CH2:27][CH2:28]2)=[N:23]1.C(Cl)(=O)CC.[CH3:46][O:47][CH2:48][C:49](Cl)=O>>[CH3:46][O:47][CH2:48][CH2:49][NH:31][C:30]1[NH:22][N:23]=[C:24]2[C:29]=1[CH2:28][CH2:27][CH2:26][N:25]2[C:32]1[C:37]([CH3:38])=[CH:36][C:35]([CH3:39])=[CH:34][C:33]=1[CH3:40]

Participants

Reactant 4

HCID 62324Propionyl chloride

HCID 96623Methoxyacetyl chloride

HCID 221362787-(2-chloro-4,6-dimethylphenyl)-2-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridin-3-ylamine

HCID 22136293HCID 22136293, compound

Product 1

HCID 69291516HCID 69291516, compound

Procedure

Compound 5-54 was prepared according to the procedure described in Example 15, steps 1 and 2, except that in step 1, 7-(2-chloro-4,6-dimethylphenyl)-2-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridin-3-ylamine (5-45) was replaced with 2-methyl-7-(2,4,6-trimethyl-phenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridin-3-ylamine (5-52) and propionyl chloride was replaced with methoxyacetyl chloride.

Sources & evidence

ORD record: ord-01c6dba779c043429c71327183decb96
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07432283B2

Reaction notes

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