1-Methyl-3-aminopyrazole → HCID 23093047, compound

HRID 2113846Notes

Reaction equation

HRID 2113846 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6](OCOC)[CH:5]=1.Br[C:17]1[CH:18]=[CH:19][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[N:21][CH:22]=1.[OH:27][C@H:28]([CH3:32])[CH2:29][O:30][CH3:31].[NH2:33][C:34]1[CH:38]=[CH:37][N:36]([CH3:39])[N:35]=1>>[CH3:26][S:23]([C:20]1[N:21]=[CH:22][C:17]([O:10][C:8]2[CH:9]=[C:4]([CH:5]=[C:6]([O:27][CH:28]([CH3:32])[CH2:29][O:30][CH3:31])[CH:7]=2)[C:3]([NH:33][C:34]2[CH:38]=[CH:37][N:36]([CH3:39])[N:35]=2)=[O:15])=[CH:18][CH:19]=1)(=[O:25])=[O:24]

Participants

5

Reactant 4

HCID 1372541-Methyl-3-aminopyrazoleHCID 2733589(R)-(-)-1-Methoxy-2-propanolHCID 134334245-Bromo-2-methanesulfonylpyridineHCID 23136427Methyl 3-hydroxy-5-(methoxymethoxy)benzoate

Product 1

HCID 23093047HCID 23093047, compound

Procedure

The compound of Production Example 144 was obtained as a colorless oil using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 5-bromo-2-methanesulfonylpyridine, (2R)-2-hydroxy-1-methoxypropane and 3-amino-1-methyl-1H-pyrazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 144 was obtained as a colorless oil

Sources & evidence

ORD record
ord-08e554253e3c4125bd89c40d786102f2
Source dataset
uspto-grants-2008_10
Patent number
US07432287B2

Reaction notes

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