1,3-Difluoro-2-propanol → 3-(6-ethanesulfonylpyridin-3-yloxy)-5-(2-fluoro-1-fluoromethyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide

HRID 2113847Notes

Reaction equation

HRID 2113847 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6](OCOC)[CH:5]=1.Br[C:17]1[CH:18]=[CH:19][C:20]([S:23]([CH2:26][CH3:27])(=[O:25])=[O:24])=[N:21][CH:22]=1.[F:28][CH2:29][CH:30]([OH:33])[CH2:31][F:32].[NH2:34][C:35]1[CH:39]=[CH:38][N:37]([CH3:40])[N:36]=1>>[CH2:26]([S:23]([C:20]1[N:21]=[CH:22][C:17]([O:10][C:8]2[CH:9]=[C:4]([CH:5]=[C:6]([O:33][CH:30]([CH2:31][F:32])[CH2:29][F:28])[CH:7]=2)[C:3]([NH:34][C:35]2[CH:39]=[CH:38][N:37]([CH3:40])[N:36]=2)=[O:15])=[CH:18][CH:19]=1)(=[O:25])=[O:24])[CH3:27]

Participants

5

Reactant 4

HCID 679851,3-Difluoro-2-propanolHCID 1372541-Methyl-3-aminopyrazoleHCID 225031645-Bromo-2-(ethylsulfonyl)pyridineHCID 23136427Methyl 3-hydroxy-5-(methoxymethoxy)benzoate

Product 1

HCID 230930353-(6-ethanesulfonylpyridin-3-yloxy)-5-(2-fluoro-1-fluoromethyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Procedure

The compound of Production Example 145 was obtained as a colorless amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 5-bromo-2-ethanesulfonylpyridine, 1,3-difluoro-2-propanol and 3-amino-1-methyl-1H-pyrazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 145 was obtained as a colorless amorphous substance

Sources & evidence

ORD record
ord-b01086aa992a4721a308ae3194a0bddd
Source dataset
uspto-grants-2008_10
Patent number
US07432287B2

Reaction notes

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