1,3-Difluoro-2-propanol → HCID 23093025, compound

HRID 2113852Notes

Reaction equation

HRID 2113852 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6](OCOC)[CH:5]=1.Br[C:17]1[CH:18]=[CH:19][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[N:21][CH:22]=1.[F:27][CH2:28][CH:29]([OH:32])[CH2:30][F:31].[NH2:33][C:34]1[S:38][N:37]=[C:36]([CH3:39])[N:35]=1>>[F:27][CH2:28][CH:29]([CH2:30][F:31])[O:32][C:6]1[CH:7]=[C:8]([O:10][C:17]2[CH:22]=[N:21][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[CH:19][CH:18]=2)[CH:9]=[C:4]([CH:5]=1)[C:3]([NH:33][C:34]1[S:38][N:37]=[C:36]([CH3:39])[N:35]=1)=[O:15]

Participants

5

Reactant 4

HCID 679851,3-Difluoro-2-propanolHCID 3506395-Amino-3-methyl-1,2,4-thiadiazoleHCID 134334245-Bromo-2-methanesulfonylpyridineHCID 23136427Methyl 3-hydroxy-5-(methoxymethoxy)benzoate

Product 1

HCID 23093025HCID 23093025, compound

Procedure

The compound of Production Example 156 was obtained as a white amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 5-bromo-2-methanesulfonylpyridine, 1,3-difluoro-2-propanol and 5-amino-3-methyl-[1,2,4]thiadiazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 156 was obtained as a white amorphous substance

Sources & evidence

ORD record
ord-aa751c4b0e684e2eb8c08a035945f24e
Source dataset
uspto-grants-2008_10
Patent number
US07432287B2

Reaction notes

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