1-Methyl-3-aminopyrazole → HCID 23093063, compound

HRID 2113854Notes

Reaction equation

HRID 2113854 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6](OCOC)[CH:5]=1.Br[C:17]1[CH:18]=[CH:19][C:20]([S:23]([CH:26]([CH3:28])[CH3:27])(=[O:25])=[O:24])=[N:21][CH:22]=1.[O:29]([CH2:37][C@H:38]([OH:40])[CH3:39])[Si](C(C)(C)C)(C)C.[NH2:41][C:42]1[CH:46]=[CH:45][N:44]([CH3:47])[N:43]=1>>[OH:29][CH2:37][CH:38]([CH3:39])[O:40][C:6]1[CH:7]=[C:8]([O:10][C:17]2[CH:22]=[N:21][C:20]([S:23]([CH:26]([CH3:28])[CH3:27])(=[O:25])=[O:24])=[CH:19][CH:18]=2)[CH:9]=[C:4]([CH:5]=1)[C:3]([NH:41][C:42]1[CH:46]=[CH:45][N:44]([CH3:47])[N:43]=1)=[O:15]

Participants

5

Reactant 4

HCID 1372541-Methyl-3-aminopyrazoleHCID 13175135(2R)-1-{[(1,1-Dimethylethyl)(dimethyl)silyl]oxy}propan-2-olHCID 13433423HCID 13433423, compoundHCID 23136427Methyl 3-hydroxy-5-(methoxymethoxy)benzoate

Product 1

HCID 23093063HCID 23093063, compound

Procedure

The compound of Production Example 159 was obtained as a white amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 5-bromo-2-isopropylsulfonylpyridine, (2R)-1-(t-butyldimethylsiloxy)-2-hydroxypropane and 3-amino-1-methyl-1H-pyrazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 159 was obtained as a white amorphous substance

Sources & evidence

ORD record
ord-8239bbe58fd94f388539ab119114e745
Source dataset
uspto-grants-2008_10
Patent number
US07432287B2

Reaction notes

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