1,3-Difluoro-2-propanol → HCID 23093075, compound

HRID 2113857Notes

Reaction equation

HRID 2113857 reaction equation
CO[C:3](=[O:15])[C:4]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6](OCOC)[CH:5]=1.I[C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1.[F:23][CH2:24][CH:25]([OH:28])[CH2:26][F:27].[NH2:29][C:30]1[CH:34]=[CH:33][N:32]([CH3:35])[N:31]=1>>[F:23][CH2:24][CH:25]([CH2:26][F:27])[O:28][C:6]1[CH:7]=[C:8]([O:10][C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH:9]=[C:4]([CH:5]=1)[C:3]([NH:29][C:30]1[CH:34]=[CH:33][N:32]([CH3:35])[N:31]=1)=[O:15]

Participants

5

Reactant 4

HCID 679851,3-Difluoro-2-propanolHCID 707143-IodopyridineHCID 1372541-Methyl-3-aminopyrazoleHCID 23136427Methyl 3-hydroxy-5-(methoxymethoxy)benzoate

Product 1

HCID 23093075HCID 23093075, compound

Procedure

The compound of Production Example 162 was obtained as a white amorphous substance using 5-hydroxy-3-methoxymethoxybenzoic acid methyl ester, 3-iodopyridine, 1,3-difluoro-2-propanol and 3-amino-1-methyl-1H-pyrazole, by the same method as in Production Example 117, a corresponding method, or a combination thereof with an ordinary method.

Workup

  1. customThe compound of Production Example 162 was obtained as a white amorphous substance

Sources & evidence

ORD record
ord-f5352a8fbfb641ea94bd86e93d6027d5
Source dataset
uspto-grants-2008_10
Patent number
US07432287B2

Reaction notes

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