反应详情

1.122 g (46.7 mmol) 95% Sodium hydride were given at −50° C. to a solution of 5.630 g (31.2 mmol) 1-allyloxy-4-chloromethyl-2-methyl-benzene and 3.525 g (31.2 mmol) 2-(1H-[1,2,3]-triazol-1-yl)-ethanol in DMF. The mixture was allowed to warm slowly to r. t., stirred for 5 hours. The mixture was concentrated in vacuo and the residue was partitioned between ethyl acetate and water. The organic layer was dried over Na2SO4 and the solvent was distilled off under reduced pressure to yield 7.30 g (86%) 1-[2-(4-Allyloxy-2-methyl-benzyloxy)-ethyl]-1H-[1,2,3]triazole as yellow oil which was used without further purification.

1. temperatureto warm slowly
2. concentrationThe mixture was concentrated in vacuo
3. customthe residue was partitioned between ethyl acetate and water
4. dry with materialThe organic layer was dried over Na2SO4
5. distillationthe solvent was distilled off under reduced pressure