Methanol → HCID 53628467, compound

Participants

Reaction Steps

In a 100 ml round flask, 2.31 g (14.1 mmol) of 3-formyl-benzoic acid methyl ester are dissolved in 25 ml of water and 45 ml of methanol and cooled to 0° C. After reaching this temperature, 980 mg (14.1 mmol) of hydroxylamine hydrochloride are added and the mixture stirred for 1 h under warming to room temperature. Then, the mixture is poured onto water and extracted twice with ethyl acetate. The organic layers are dried with brine and over Na2SO4 and concentrated. This yields the title compound as a white solid which is used for the next step without purification. Mass spectrum: m/z (M+H)+: 179.9

Provenance & Evidence