Pyridine → HCID 57907147, compound

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Reaction Steps

In a 10 ml round flask, 500 mg (2.9 mmol) of 3-ethynyl-benzoic acid ethyl ester and 652 mg (3.5 mmol, 1.2 eq.) of 4-chloro-N-hydroxy-benzenecarboximidoyl chloride are dissolved in 4 ml of CHCl3. To this solution, 11 mg (0.14 mmol, 0.05 eq.) of pyridine and 290 mg (2.9 mmol) of triethyl amine are added at 0° C. under a nitrogen atmosphere. The orange solution is stirred under warming to room temperature for 20 h. The suspension is filtered and the solution concentrated in vacuo. Chromatographical purification (100 g SiO2; eluent: hexane/ethyl acetate 9:1) yields the title compound as a white solid. Mass spectrum: m/z (M+H)+: 328.2; 330.2

Provenance & Evidence