Lithium Hydroxide → HCID 57907221, compound

Participants

Reaction Steps

In a 25 ml round flask, 250 mg (0.76 mmol) of 3-[3-(4-chloro-phenyl)-isoxazol-5-yl]-benzoic acid ethyl ester are dissolved in 5 ml of dioxane. After addition of 1M aqueous lithium hydroxide (0.99 ml, 0.99 mmol, 1.3 eq.), the mixture is stirred at room temperature for 20 h. Then, the dioxane is removed in vacuo, 5 ml of water is added and the pH adjusted to 2 by addition of 1M hydrochloric acid. The precipitate is filtered off, washed with water and dried. This yields the title compound as a white solid. Mass spectrum: m/z (M−H)−: 298.1; 300.1

Provenance & Evidence