Triethylamine → N-{5-[2-(4-Fluoro-phenylamino)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-methanesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	Methanesulfonyl chloride	HCID 31297	—
Reactant	[4-(2-Amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-fluoro-phenyl)-amine	HCID 9857535	—
Solvent	Dimethylformamide	HCID 6228	—
Product	N-{5-[2-(4-Fluoro-phenylamino)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-methanesulfonamide	HCID 10091115	—

Reaction Steps

This compound was prepared from [4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-fluoro-phenyl)-amine by treatment with methylsulfonyl chloride and Et3N in DMF. Gray solid; 1H-NMR (DMSO-d6) δ: 3.31 (s, 3H, CH3), 3.63 (s, 3H, CH3), 7.32 (m, 1H, pyrimidinyl-H), 7.42 (m, 2H, Ph-H), 8.11 (m, 2H, Ph-H), 8.63 (d, 1H, J=5.0 Hz, pyrimidinyl-H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07432260B2
Source dataset	uspto-grants-2008_10
ORD ID	ord-79311b7f883a470a9cae20bab9d5e51b
Source note	uspto-grants-2008_10