3-Dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone → HCID 11724775, compound

HRID 2113970Notes

Reaction equation

HRID 2113970 reaction equation
[CH3:1][C:2]1[N:6]=[C:5]([CH3:7])[S:4][C:3]=1/[CH:8]=[CH:9]/[C:10](N(C)C)=O.[N+]([O-])(O)=O.[C:19]([NH:22][C:23]1[CH:28]=[CH:27][C:26]([NH:29][C:30]([NH2:32])=[NH:31])=[CH:25][CH:24]=1)(=[O:21])[CH3:20]>>[CH3:7][C:5]1[S:4][C:3]([C:8]2[CH:9]=[CH:10][N:32]=[C:30]([NH:29][C:26]3[CH:27]=[CH:28][C:23]([NH:22][C:19](=[O:21])[CH3:20])=[CH:24][CH:25]=3)[N:31]=2)=[C:2]([CH3:1])[N:6]=1

Participants

3

Reactant 2

HCID 916216443-Dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenoneHCID 178474259HCID 178474259, compound

Product 1

HCID 11724775HCID 11724775, compound

Procedure

By condensation between 3-dimethylamino-1-(2,4-dimethyl-thiazol-5-yl)-propenone and N-(4-acetamidophenyl)-guanidine nitrate. Pale solid. Mp. 219-220° C. 1H-NMR (DMSO-D6) δ: 2.00 (s, 3H, CH3), 2.61 (s, 3H, CH3), 2.64 (s, 3H, CH3), 7.04 (d, 1H, J=4.9 Hz, pyrimidinyl-H), 7.48 (d, 2H, J=8.8 Hz, Ph-H), 7.64 (d, 2H, J=8.8 Hz, Ph-H), 8.47 (d, 1H, J=5.4 Hz, pyrmidinyl-H), 9.58 (s, 1H, NH), 9.82 (s, 1H, NH). MS (ESI+) m/z 340.02 [M+H]+ (C17H17N5OS requires 339.42).

Sources & evidence

ORD record
ord-a6155513945948068eaa57e8dfd94074
Source dataset
uspto-grants-2008_10
Patent number
US07432260B2

Reaction notes

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