1-Chloro-2-propanol → HCID 10002486, compound

HRID 2113971Notes

Reaction equation

HRID 2113971 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:20]=[CH:19][C:18]([N:21]4[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]4)=[CH:17][CH:16]=3)[N:9]=2)=[C:5]([CH3:7])[N:6]=1.Cl[CH2:28][CH:29]([OH:31])[CH3:30]>>[CH3:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:16]=[CH:17][C:18]([N:21]4[CH2:22][CH2:23][N:24]([CH2:28][CH:29]([OH:31])[CH3:30])[CH2:25][CH2:26]4)=[CH:19][CH:20]=3)[N:9]=2)=[C:5]([CH3:7])[N:6]=1

Participants

3

Reactant 2

HCID 313701-Chloro-2-propanolHCID 10090332HCID 10090332, compound

Product 1

HCID 10002486HCID 10002486, compound

Procedure

By treatment of [4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-piperazin-1-yl-phenyl)-amine with 1-chloro-2-propanol. 1H-NMR (CDCl3) δ: 1.10 (d, 3H, J=6.0 Hz, CH3), 2.26-2.33 (m, 2H, CH2), 2.49-2.53 (m, 2H, CH2), 2.61 (s, 3H, CH3), 2.63 (s, 3H, CH3), 2.76-2.80 (m, 2H, CH2), 3.07-3.13 (m, 4H, CH2), 3.83 (m, 1H, CH), 6.81 (d, 1H, J=4.4 Hz, pyrimidinyl-H), 6.88 (d, 2H, J=8.8 Hz, Ph-H), 7.02 (brs, 1H, OH), 7.44 (d, 2H, J=8.8 Hz, Ph-H), 8.30 (d, 1H, J=4.4 Hz, pyrimidinyl-H).

Sources & evidence

ORD record
ord-d2667c112d484446a552053a3011db87
Source dataset
uspto-grants-2008_10
Patent number
US07432260B2

Reaction notes

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