Morpholine → HCID 10432476, compound

HRID 2113973Notes

Reaction equation

HRID 2113973 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13]2[N:18]=[C:17]([C:19]3[S:23][C:22]([CH3:24])=[N:21][C:20]=3[CH3:25])[CH:16]=[CH:15][N:14]=2)=[CH:8][CH:7]=1)=[O:4].[NH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[CH3:24][C:22]1[S:23][C:19]([C:17]2[CH:16]=[CH:15][N:14]=[C:13]([NH:12][C:9]3[CH:10]=[CH:11][C:6]([NH:5][C:3](=[O:4])[CH2:2][N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)=[CH:7][CH:8]=3)[N:18]=2)=[C:20]([CH3:25])[N:21]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 9999443HCID 9999443, compound

Product 1

HCID 10432476HCID 10432476, compound

Procedure

By treatment of 2-chloro-N-{4-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenyl}-acetamide with morpholine. 1H-NMR (DMSO-D6) δ: 2.61 (s, 3H, CH3), 2.64 (s, 3H, CH3), 3.09 (s, 2H, CH2), 3.27-3.31 (m, 4H, CH2), 3.62-3.64 (m, 4H, CH2), 7.04 (d, 1H, J=5.4 Hz, pyrimidinyl-H), 7.54 (d, 2H, J=8.8 Hz, Ph-H), 7.67 (d, 2H, J=8.8 Hz, Ph-H), 8.48 (d, 1H, J=4.9 Hz, pyridinyl-H), 9.59 (s, 1H, NH). MS (ESI+) m/z 425.01 [M+H]+ (C21H24N6O2S requires 424.52).

Sources & evidence

ORD record
ord-fa90e2a1e914461998fa2704397513b6
Source dataset
uspto-grants-2008_10
Patent number
US07432260B2

Reaction notes

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