Hydrochloric Acid → HCID 59811898, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 61 (0.017 g, 0.038 mmol), 10% hydrochloric acid (1 mL), and ethanol (1 mL) was heated at 80° C. for 30 minutes. The mixture was cooled and poured into saturated NaHCO3 solution and extracted with AcOEt. The organic extract was dried (MgSO4), concentrated and purified by means of preparative TLC with CH2Cl2:methanol as eluent to afford 62 (0.0047 g, 39%) as a tan solid. 1H NMR (400 MHz, CDCl3) δ 2.94 (s, 6H), 3.02-3.06 (m, 4H), 3.86-3.90 (m, 4H), 6.75-6.81 (m, 3H), 7.42-7.47 (m, 2H), 7.97 (d, J=0.21 Hz, 1H), 8.44 (d, J=0.21 Hz, 1H), 8.74 (bs, 1H).

Provenance & Evidence