202599-49-3 → HCID 69200844, compound

HRID 2114095Notes

Reaction equation

HRID 2114095 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:21])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([NH:16][CH2:17][CH:18]3[CH2:20][CH2:19]3)=[O:15])=[CH:10][CH:9]=2)[CH:7]=1.[N:22]1([C:28]2[CH:37]=[C:36]([C:38](O)=[O:39])[C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[N:29]=2)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH:18]1([CH2:17][NH:16][C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]3[C:5]([CH3:21])=[CH:4][CH:3]=[C:2]([NH:1][C:38]([C:36]4[C:35]5[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=5)[N:29]=[C:28]([N:22]5[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]5)[CH:37]=4)=[O:39])[CH:7]=3)=[CH:9][CH:10]=2)=[O:15])[CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 230593202599-49-3HCID 113004885'-amino-N-(cyclopropylmethyl)-2'-methyl-1,1'-biphenyl-4-carboxamide

Product 1

HCID 69200844HCID 69200844, compound

Procedure

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)-2-piperidin-1-ylquinoline-4- carboxamide was prepared from 5′-amino-N-(cyclopropylmethyl)-2′-methyl-1, 1′-biphenyl-4-carboxamide and 2-(piperidin-1-yl)quinoline-4-carboxylic acid using method B. NMR; δH CDCl3 7.90,(1H, d), 7.83-7.78,(4H, m), 7.67,(1H, b), 7.52,(1H, t), 7.42,(2H, d), 7.33,(1H, d), 7.26, (1H, m), 7.21,(1H, t), 7.01,(1H, s), 6.30,(1H, t), 3.63,(4H, s), 3.31,(2H, m), 2.27,(3H, s), 1.62,(6H, m), 1.07,(1H, m), 0.57,(2H, m), 0.28,(2H, m). LCMS: retention time 3.32 min, MH+519.

Sources & evidence

ORD record
ord-abe3b9afa95e40b4842f4f6023bf9437
Source dataset
uspto-grants-2008_10
Patent number
US07432289B2

Reaction notes

Loading…