Pyrrolidine → HCID 44578672, compound

Participants

Reaction Steps

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)-2-pyrrolidin-1- ylisonicotinamide was prepared from 2-chloro-N-(4′-{[(cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)isonicotinamide and pyrrolidine using method A. NMR; δH [2H6]—DMSO 10.28,(1H. s), 8.62,(1H, t), 8.19,(1H, d), 7.93,(2H, d), 7.71,(1H, dd), 7.66,(1H, d), 7.44,(2H, d), 7.30,(1H, d), 6.97,(1H, d), 6.86,(1H, s), 3.43,(4H, m), 3.16,(2H, t), 2.20,(3H, s), 1.95,(4H, m), 1.04,(1H, b), 0.43,(2H, m), 0.24,(2H, m). LCMS: retention time 2.85 min, M+455.

Provenance & Evidence