Morpholine → HCID 24856364, compound

Participants

Reaction Steps

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)-2-morpholin-4- ylisonicotinamide was prepared from 2-chloro-N-(4′-{[(cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)isonicotinamide and morpholine using method A. NMR; δH [2H6]—DMSO 10.32,(1H, s), 8.62,(1H, t), 8.27,(1H, d), 7.93,(2H, d), 7.70,(1H, dd), 7.64,(1H, d), 7.44,(2H, d), 7.30,(1H, d), 7.24,(1H, s), 7.11,(1H, d), 3.71,(4H, m), 3.51,(4H, m), 3.16,(2H, t), 2.20,(3H, s), 1.05,(1H, m), 0.43,(2H, m), 0.24,(2H, m). LCMS: retention time 3.31 min, MH+471.

Provenance & Evidence