Isobutylamine → HCID 44578747, compound

HRID 2114102Notes

Reaction equation

HRID 2114102 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][N:30]=1)[C:5]([NH:7][C:8]1[CH:9]=[C:10]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([NH:23][CH2:24][CH:25]3[CH2:27][CH2:26]3)=[O:22])=[CH:17][CH:16]=2)[C:11]([CH3:14])=[CH:12][CH:13]=1)=[O:6].[CH2:31]([NH2:35])[CH:32]([CH3:34])[CH3:33]>>[CH:25]1([CH2:24][NH:23][C:21]([C:18]2[CH:19]=[CH:20][C:15]([C:10]3[C:11]([CH3:14])=[CH:12][CH:13]=[C:8]([NH:7][C:5](=[O:6])[C:4]4[CH:28]=[CH:29][N:30]=[C:2]([NH:35][CH2:31][CH:32]([CH3:34])[CH3:33])[CH:3]=4)[CH:9]=3)=[CH:16][CH:17]=2)=[O:22])[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 6558IsobutylamineHCID 44578670HCID 44578670, compound

Product 1

HCID 44578747HCID 44578747, compound

Procedure

N-(4′-{[(Cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)-2-(isobutylamino)isonicotinamide was prepared from 2-chloro-N-(4′-{[(cyclopropylmethyl)amino]carbonyl}-6-methyl-1,1′-biphenyl-3-yl)isonicotinamide and isobutylamine using method C. NMR; δH [2H6]-DMSO 10.27,(1H, s), 8.62,(1H, t), 8.07,(1H, d), 7.93,(2H, d), 7.70-7.66,(2H, m), 7.43,(2H, d), 7.28,(1H, d), 6.88-6.84,(3H, m), 3.16,(2H, t), 3.09,(2H, t), 2.20,(3H, s), 1.83,(1H, m), 1.04,(1H, m), 0.90,(6H, d), 0.43,(2H, m), 0.24,(2H, m). LCMS: retention time 3.02 min, MH+457.

Sources & evidence

ORD record
ord-07fb2c84952b42bd8b83af74b169c5d1
Source dataset
uspto-grants-2008_10
Patent number
US07432289B2

Reaction notes

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